Pep Guardiola faces a monumental injury crisis as Manchester City gear up for a crucial showdown with Arsenal at the Etihad Stadium.

The reigning champions are set to host their Premier League rivals in a highly anticipated match that could sway the title race.

However, City find themselves grappling with the potential absence of seven key players, including doubts over the fitness of star midfielder Kevin De Bruyne.

Injuries sustained during international duty threaten to sideline Kyle Walker, John Stones, and Manuel Akanji, posing significant defensive challenges for Guardiola with three key defenders potentially unavailable.

De Bruyne’s possible absence looms large, while concerns also surround the availability of Jack Grealish and Matheus Nunes, who are racing against time to recover for the Etihad clash.

Additionally, Brazilian goalkeeper Ederson’s status remains uncertain following his premature departure in the recent draw against Liverpool.

Matheus Nunes, although primarily a squad player since his summer transfer from Wolves, suffered a foot injury prompting his withdrawal from the Portuguese national team during the break.

De Bruyne, managing a groin concern, participated in a session with City’s Under-23s, possibly featuring on the bench if not fully fit.

Despite City’s strong historical record against Arsenal, particularly at home, the absence of several key players presents a significant test of their squad depth against the league leaders.

Arsenal secured a narrow 1-0 victory over City earlier in the season at the Emirates Stadium.

Guardiola’s side faces a demanding fixture schedule, with seven matches scheduled before April 20, including crucial encounters in the Premier League, Champions League quarter-finals against Real Madrid, and an FA Cup semi-final against Chelsea.

As they aim to replicate last season’s historic treble, City must rely on their top performers to maintain their pursuit of multiple honors.

Meanwhile, Arsenal manager Mikel Arteta awaits updates on the fitness of Bukayo Saka and Gabriel, both of whom withdrew from international duty due to injury concerns.

Saka’s muscle issue forced his withdrawal from the squad last week, adding to the uncertainty surrounding Arsenal’s lineup for the trip to Manchester.